Cushing's disease is a condition caused by abnormally high levels of the hormone cortisol circulating throughout the bloodstream. It can be caused by taking too many corticosteroids or by a tumor that secretes cortisol or other hormones which cause cortisol to be made. Because Cushing's disease alters hormone levels, it has a myriad of symptoms.
Changes in Weight
Often the first symptom observed in Cushing's disease is sudden weight gain. It typically affects the trunk the most.
Other Weight Gain Features
People with Cushing's disease often develop a small pad at the back of the neck along the collar bone, known as a buffalo hump. They may also develop a roundish face, which is known as moon face.
Bruising
Cushing's disease often leads to capillary dilation as well as the skin becoming thinner. This causes bruising.
Other Hormonal Issues
The effects of Cushing's disease can cause excessive urination, high blood pressure and resistance to insulin (leading to diabetes).
Psychological Effects
The hormonal imbalance caused by Cushing's disease can lead to certain psychological disorders, such as depression and anxiety.
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