Plavix, or clopidogrel, is a prescription medication used to treat coronary and vascular disease. It contains an antiplatelet agent that inhibits the ability of platelets and blood cells to aggregate and stick to the walls of blood vessels. Although Plavix is generally well-tolerated, it has garnered media and medical attention because of its potential for several potentially serious side effects.
Hemorrhage
The most frequently reported serious side effect of Plavix is due to its "thinning" the blood. Plavix may increase the risk of internal or external bleeding and increase the time needed for bleeding to stop. Plavix should be used with caution in patients who have bleeding lesions (such as ulcers), who have bleeding disorders (such as hemophilia), or who are concurrently taking aspirin or other blood-thinning medications. Patients taking Plavix should seek immediate medical attention if they experience excessive bruising or have a cut that will not stop bleeding. Patients should also notify their health care providers that they are taking Plavix at least five days before undergoing any surgical procedures.
Thrombotic Thrombocytopenic Purpura
Thrombotic thrombocytopenic purpura, or TTP, is a disorder that causes clots to form in small blood vessels. According to Bristol-Myers Squibb, the manufacturer of Plavix, "TTP has been reported rarely following use of Plavix, sometimes after a short exposure (less than two weeks)." Symptoms of TTP include hallucinations and other neurological disturbances, fever, low-platelet count, and renal issues. If you exhibit any of these symptoms, contact your health care provider immediately. TTP can become fatal quickly.
Neutropenia/Agranulocytosis
An uncommon but serious reported side effect of Plavix is neutropenia and agranulocytosis, a condition in which either the bone marrow ceases producing an adequate number of neutrophils (white blood cells) or the body destroys circulating neutrophils. It decreases the body's abilities to fight infections and can become fatal. These conditions can develop quickly or progressively. If you are taking Plavix and suspect neutropenia or agranulocytosis, ask your health care provider for a blood test and bone marrow sample test.
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